- High titration in Glucoraphanin ( >10%) and Myrosinase
- Innovative formulation in chewable tablets
- Patented production process
- Modulates the inflammatory response
- Promotes the body’s purifying functions
- Stimulates endogenous antioxidant activity
COME AGISCE
Sulforaphane promotes cellular health through the induction of phase 2 enzymes that promote endogenous antioxidant, detoxification and inflammation-modulating activity
INDICAZIONI D'USO
- Depurativo disintossicante
- Coadiuvante nella funzionalità epatica e renale
- Riduzione dello stress ossidativo
ACTisulf®
SULFORAFANO ATTIVATO
CONTENUTO CONFEZIONE
30 Compresse
FORMULAZIONE
Compresse masticabili
AVVERTENZE
Non superare la dose consigliata.
Sconsigliato in gravidanza, nei bambini, nell’uso prolungato senza parere medico.
Un consumo eccessivo può avere effetti lassativi.
CODICE MINISTERIALE
974886867
DETTAGLI
FONTE DI ESTRAZIONE
Il sulforafano è un composto bioattivo appartenente alla classe degli isotiocianati, presenti principalmente nei vegetali cruciferi come il broccolo, i cavoli e i cavolfiori. La tecnica di estrazione brevettata consente la conservazione delle proprietà fitochimiche della materia prima.
SULFORAFANO ATTIVATO
ACTisulf® è un innovativo integratore alimentare a base di un estratto brevettato di germogli di broccoli titolato in Sulforafano Attivato e naturalmente ricco di glucosinolati, precursori di isotiocianati ed indoli fisiologicamente attivi. Actisulf® utilizza un processo produttivo brevettato che consente la preservazione dei costituenti essenziali della molecola, inoltre è titolato in Mirosinasi, un enzima fondamentale per la conversione ottimale della Glucorafanina in Sulforafano.
BENEFICI PER LA SALUTE
I Beta-glucani sono polisaccaridi che fanno parte della parete cellulare di funghi, piante e batteri (Gawronski et al., 1999).
La frazione di Beta-glucani digerita nell’intestino crasso dà origine a glicosidi e oligosaccaridi bioattivi, le cui proprietà biologiche non sono ancora del tutto note, ma giustificano il loro ruolo nei processi immunitari. La particolare struttura conferisce loro una certa flessibilità, influenzando le funzioni metaboliche, in particolare le attività ipocolesterolemizzanti, ipoglicemizzanti ed immunomodulanti.
STUDI CLINICI DIETRO IL PRODOTTO
Studies have shown that sulforaphane is the most potent natural stimulator of NRF2, a transcription factor that regulates gene expression of numerous antioxidant cytoprotective enzymes of detoxification phase 2. NRF2 which in healthy subjects is activated on average every 129 minutes, stimulated by Sulforaphane, is activated every 80 minutes allowing to significantly enhance the physiological antioxidant and detoxifying activities of the organism.
The modulating effects on inflammatory processes of sulforaphane are mediated by preventing the translocation of NF-kB into the nucleus, interrupting the cascade system of pro-inflammatory signals at the endocellular level. 12
Recent clinical studies indicate a possible positive correlation between sulforaphane supplementation and improvements in behavior and social interaction in individuals with autism spectrum disorders. 21,22,23,24,
According to various studies, sulforaphane has a positive effect on glucose metabolism, regulating blood levels.2°
The chemoprotective activity of sulforaphane is the subject of a growing body of study. 1,2,4,5,6,7,8,9,10,13,14,15,16
RIFERIMENTI
1. Li, Y. et al. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res. 16,2580–2590 (2010).
2. Antioxidant functions of sulforaphane a potent inducer of Phase II detoxication enzymes JW Fahey, PTalalay – Food and Chemical Toxicology, 1999
3. Sulforaphane Causes Autophagy to Inhibit Release of Cytochrome and Apoptosis in Human Prostate Cancer Cells Anna Herman-Antosiewicz, (Cancer research, 2006)
4. Cruciferous vegetables, mushrooms, and gastrointestinal cancer risks in a multicenter, hospital-based case-control study in Japan. Hara M, Hanaoka T, Kobayashi M, et al. (Nutr Cancer 46:138-147, 2003).
5. Nucleotide excision repair gene polymorphisms and recurrence after treatment for superficial bladder cancer. Gu J, Zhao H, Dinney CP, et al (Clin Cancer Res 11:1408-1415, 2005.)
6. Sulforaphane suppresses EMT and metastasis in human lung cancer through miR616-5p-mediated GSK3B/B-catenin signaling pathways. Wang DX, Zou YJ, Zhuang XB, Chen SX, Lin Y, LI WL, Lin JJ, Lin ZQ(Acta Pharmacol Sin 2017;38:241-251)
7. Isothiocyanates in the chemoprevention of bladder cancer. TangLand Zhang Y: (Curr Drug Metab 5: 193-201, 2004.)
8. Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells. Tang Land Zhang Y (J Nutr 134:2004-2010, 2004)
9. Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. Kelloff GJ, Crowell JA, Steele VE, et al: (J Nutr 130:467S-4715, 2000.)
10. Effect of sulforaphane on cell growth, GO/G1 phase cell progression and apoptosis in human bladder cancer T24 cells YUJUAN SHAN at all. (INTERNATIONAL JOURNAL OF ONCOLOGY 29:883-888, 2006)
11. Prevention of Diabetic Nephropathy by Sulforaphane: Possible Role of Nrf2 Upregulation and Activation. Wenpeng Cui,1,2 Yang Bai At all.
12. Heiss E, et al. Nuclear factor kappa Bisa molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem. (2001)
13. Ocker M, Schneider-Stock R. Histone deacetylase inhibitors: signalling towards p21 cip1/waf1. Int J Biochem Cell Biol. (2007)
14. Myzak MC, et al.A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res. (2004)
15. Furniss CS, et al. Polyamine metabolism and transforming growth factor-beta signaling are affected in Caco-2 cells by differentially cooked broccoli extracts. J Nutr. (2008)
16. L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells Su-Hyeong Kim and Shivendra V.Singh (Molecular cancer Therapeutics, 2009)
17. Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status:a mendelian randomisation approach. Brennan P, Hsu CC, Moullan N, et al (Lancet 366:1558-1560, 2005).
18. Efficacy of sulforaphane in eradicating Helicobacter pylori in human gastric xenografts implanted in nude mice. Haristoy X1, Angioi-Duprez K, DuprezA, Lozniewski A. (Antimicrob Agents Chemother. 2003)
19. Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury. Kazutaka Yoshida, Yusuke Ushida, Tomoko Ishijima, Hiroyuki Suganuma, Takahiro Inakuma, Nobuhiro Yajima, Keiko Abe, and Yuji Nakai (World J Gastroenterol. 2015)
20. Annika S. Axelsson, Emily Tubbs e Brig Mecham, Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes, Science Translational Medicine, vol. 9, n°394, 14 giugno 2017
21. Greer McGuinness, Yeonsoo Kim. SULFORAPHANE TREATMENT FOR AUTISM SPECTRUM. EXCLI Journal. 2020, p. 19:892-90.
22. Hua Liu, Andrew W. Zimmerman, Kanwaljit Singh, Susan L. Connors, Eileen Diggins, Katherine K. Stephenson, Albena T. Dinkova-Kostova & Jed W. Fahey. Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder. 2020, 10:5822.
23. Bent S, Lawton B, Warren T, Widjaja F, Dang K, Fahey JW, et al. Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. Mol Autism. 2018, 9:35.
24. Zimmerman. Sulforaphane-rich broccoli sprout extract for autism. Study Results. s.l. : ClinicalTrials.gov. [last update posted Sept 12, 2018].
SHERMAN TREE PRESENT
I nostri partner
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